RG7109

RG7109 is an inhibitor of HCV NS5B polymerase. RG7109 has EC50 values of 1.1 nM and 1.0 nM for HCV GT-1a H77 and GT-1b Con1, respectively. RG7109 exhibits favorable pharmacokinetic properties and can be used in anti-HCV research[1].

Product Specifications

CAS Number

[1257830-82-2]

UNSPSC

12352005

Target

DNA/RNA Synthesis; HCV

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

CS(=O)(NC1=CC=C(C2=CC3=C(OC)C(C(C)(C)C)=CC(C4=CC=C(OC)NC4=O)=C3N=C2)C=C1)=O

Molecular Formula

C27H29N3O5S

Molecular Weight

507.60

References & Citations

[1]Talamas FX, et al. Discovery of N-[4-[6-tert-butyl-5-methoxy-8- (6-methoxy-2-oxo-1H-pyridin-3-yl) -3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase. J Med Chem. 2014 Mar 13;57 (5) :1914-31.