L-657743
L-657743 is a highly potent, highly selective, and orally active α2-adrenoceptor antagonist. L-657743 can be used in the research of neurological diseases such as depression[1].
Product Specifications
CAS Number
111466-41-2
UNSPSC
12352005
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C1N(C)[C@]2(CCN1C)CCN3CCC4=C(OC5=CC=CC=C54)[C@]3([H])C2
Molecular Formula
C20H25N3O2
Molecular Weight
339.43
References & Citations
[1]Pettibone DJ, et al. Pharmacological profile of a new potent and specific alpha 2-adrenoceptor antagonist, L-657,743. Naunyn Schmiedebergs Arch Pharmacol. 1987 Aug;336 (2) :169-75.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
α adrenergic receptor
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC880096-500 1x 500 µL
Histone H1 (AE-4), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC941231-500 1x 500 µL
Eosinophil Peroxidase (AHE-1), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC472848-500 1x 500 µL
Fibronectin (Fn-3), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC881981-100 1x 100 µL
Elastin (ELN) (Marker of Arterial Stiffness and Atherosclerosis) (ELN/1981), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details