AMG-126737
AMG-126737 is an orally active and highly selective human mast cell tryptase inhibitor with a Ki of 90 nM. AMG-126737 suppresses early/late-phase bronchoconstriction in sheep models. AMG-126737 is promising for research of asthma and allergic diseases[1].
Product Specifications
CAS Number
224054-76-6
UNSPSC
12352005
Target
Ser/Thr Protease
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=S(NCC1=CC=C(OCCCCCOC2=CC=C(CNS(=O)(C3=CC(C(N)=N)=CC=C3)=O)C=C2)C=C1)(C4=CC(C(N)=N)=CC=C4)=O
Molecular Formula
C33H38N6O6S2
Molecular Weight
678.82
References & Citations
[1]Wright CD, et al. Inhibition of allergen-induced pulmonary responses by the selective tryptase inhibitor 1,5-bis-[4-[ (3-carbamimidoyl-benzenesulfonylamino) -methyl]-phenoxy]-pen tane (AMG-126737) . Biochem Pharmacol. 1999 Dec 15;58 (12) :1989-96.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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