AMG-126737

AMG-126737 is an orally active and highly selective human mast cell tryptase inhibitor with a Ki of 90 nM. AMG-126737 suppresses early/late-phase bronchoconstriction in sheep models. AMG-126737 is promising for research of asthma and allergic diseases[1].

Product Specifications

CAS Number

[224054-76-6]

UNSPSC

12352005

Target

Ser/Thr Protease

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

O=S(NCC1=CC=C(OCCCCCOC2=CC=C(CNS(=O)(C3=CC(C(N)=N)=CC=C3)=O)C=C2)C=C1)(C4=CC(C(N)=N)=CC=C4)=O

Molecular Formula

C33H38N6O6S2

Molecular Weight

678.82

References & Citations

[1]Wright CD, et al. Inhibition of allergen-induced pulmonary responses by the selective tryptase inhibitor 1,5-bis-[4-[ (3-carbamimidoyl-benzenesulfonylamino) -methyl]-phenoxy]-pen tane (AMG-126737) . Biochem Pharmacol. 1999 Dec 15;58 (12) :1989-96.