Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Prucalopride (succinate) (Standard)

Prucalopride (succinate) (Standard) is the analytical standard of Prucalopride (succinate) . This product is intended for research and analytical applications. Prucalopride succinate is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride succinate improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride succinate also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride succinate can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer[1][2][3][4].

Product Specifications

CAS Number

179474-85-2

UNSPSC

12352100

Target

5-HT Receptor; Apoptosis; Autophagy; Reference Standards

Related Pathways

Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Cancer; Metabolic Disease

Smiles

O=C(O)CCC(O)=O.O=C(C1=C(OCC2)C2=C(N)C(Cl)=C1)NC3CCN(CCCOC)CC3

Molecular Formula

C22H32ClN3O7

Molecular Weight

485.96

References & Citations

[1]Briejer MR, et al. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001 Jun 29;423 (1) :71-83.|[2]Johnson DE, et al. The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations. J Pharmacol Exp Ther. 2012 Jun;341 (3) :681-91.|[3]Wang Y, et al. Prucalopride might improve intestinal motility by promoting the regeneration of the enteric nervous system in diabetic rats. Int J Mol Med. 2022 Jul;50 (1) :87.|[4]Chen M, et al. Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway. Hum Exp Toxicol. 2020 Feb;39 (2) :173-181.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

BMF (BH3 Domain) Rabbit Polyclonal Antibody
AP11302PU-N 400 µL

BMF (BH3 Domain) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
BTG2 Mouse Monoclonal Antibody [Clone ID: OTI2F3]
CF808150 100 µg

BTG2 Mouse Monoclonal Antibody [Clone ID: OTI2F3]

Sign In for Pricing
View Details
CD1B Mouse Monoclonal Antibody [Clone ID: CC20]
AM01064RP-N 100 Tests

CD1B Mouse Monoclonal Antibody [Clone ID: CC20]

Sign In for Pricing
View Details
VEGF-R2 / CD309 / Flk-1 / KDR3 (DC101), CF488A conjugate, 0.1mg/mL
BNC880531-500 1x 500 µL

VEGF-R2 / CD309 / Flk-1 / KDR3 (DC101), CF488A conjugate, 0.1mg/mL

Sign In for Pricing
View Details
UBE2G1 Human Gene Knockout Kit (CRISPR)
KN401159 1 Kit

UBE2G1 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
Trap1 Antibody: ATTO 594
SMC-207D-A594 100 µg

Trap1 Antibody: ATTO 594

Sign In for Pricing
View Details