Mitapivat (hydrochloride)

Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric pyruvate kinase R (PK-R) activator. Mitapivat hydrochloride accelerates the reaction of PK-R catalyzing the conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolytic pathway, increasing the production of adenosine triphosphate (ATP) in red blood cells, and reducing the level of 2,3-diphosphoglycerate (2,3-DPG) . Mitapivat hydrochloride is promising for research of pyruvate kinase deficiency and other anemia-related diseases[1].

Product Specifications

CAS Number

[2559738-69-9]

Product Name Alternative

AG-348 (hydrochloride)

UNSPSC

12352005

Target

Pyruvate Kinase

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Smiles

O=S(C1=C2N=CC=CC2=CC=C1)(NC3=CC=C(C(N4CCN(CC5CC5)CC4)=O)C=C3)=O.[H]Cl

Molecular Formula

C24H27ClN4O3S

Molecular Weight

487.01

References & Citations

[1]Yang H, et al. Phase 1 Single- and Multiple-Ascending-Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers. Clin Pharmacol Drug Dev. 2019 Feb;8 (2) :246-259.