BPTES (Standard)

BPTES (Standard) is the analytical standard of BPTES. This product is intended for research and analytical applications. BPTES is an allosteric and selective glutaminase inhibitor with an IC50 of 0.16 μM.

Product Specifications

CAS Number

[314045-39-1]

UNSPSC

12352100

Target

Glutaminase; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

O=C(NC1=NN=C(CCSCCC2=NN=C(NC(CC3=CC=CC=C3)=O)S2)S1)CC4=CC=CC=C4

Molecular Formula

C24H24N6O2S3

Molecular Weight

524.68

References & Citations

[1]Elgogary A, et al. Combination therapy with BPTES nanoparticles and targets the metabolic heterogeneity of pancreatic cancer. Proc Natl Acad Sci U S A. 2016 Sep 6;113 (36) :E5328-36.|[2]Meghan J. Seltzer, et al. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res. 2010 Nov 15; 70 (22) : 8981-8987.|[3]Lee JS, et al. Glutaminase 1 inhibition reduces thymidine synthesis in NSCLC. Biochem Biophys Res Commun. 2016 Aug 26;477 (3) :374-82|[4]Lee JS, et al. Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC. Cell Death Dis. 2016 Dec 8;7 (12) :e2511.