PF-06658607
PF-06658607 is an alkynylated irreversible Brutons tyrosine kinase (BTK) inhibitor that covalently reacts with active site cysteines in the ATP-binding pocket. PF-06658607 can be used to detect "off "-targets for covalent kinase inhibitors in cancer cells. The alkyne moiety allows for azide-based detection probe via copper-catalyzed click chemistry[1].
Product Specifications
CAS Number
[1621002-24-1]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Btk
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=CC(N1C[C@H](N2N=C(C3=CC=C(OC4=CC=CC(C#C)=C4)C=C3)C5=C(N)N=CN=C52)CCC1)=O
Molecular Formula
C27H24N6O2
Molecular Weight
464.52
Precautions
H315, H319, H335
References & Citations
[1]Lanning BR, et al. A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors. Nat Chem Biol. 2014 Sep;10 (9) :760-767.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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