4-Hydroxyresveratrol
4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene), a Resveratrol analog, differentially induces pro-apoptotic p53/Bax gene expression. 4-Hydroxyresveratrol induces apoptosis in SV40 virally transformed WI38 cells (WI38VA) cells, but not in WI38 cells. 4-Hydroxyresveratrol significantly induces the expression of p53, GADD45 and Bax genes and concomitantly suppresses the expression of bcl-2 gene in WI38VA[1].
Product Specifications
CAS Number
331443-00-6
Product Name Alternative
3,4,5,4'-Tetrahydroxystibene
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; Bcl-2 Family; MDM-2/p53
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
OC1=CC(/C=C/C2=CC=C(O)C=C2)=CC(O)=C1O
Molecular Formula
C14H12O4
Molecular Weight
244.24
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax
Frequently Asked Questions
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