4-Hydroxyresveratrol

4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene), a Resveratrol (HY-16561) analog, differentially induces pro-apoptotic p53/Bax gene expression. 4-Hydroxyresveratrol induces apoptosis in SV40 virally transformed WI38 cells (WI38VA) cells, but not in WI38 cells. 4-Hydroxyresveratrol significantly induces the expression of p53, GADD45 and Bax genes and concomitantly suppresses the expression of bcl-2 gene in WI38VA[1].

Product Specifications

CAS Number

[331443-00-6]

Product Name Alternative

3,4,5,4'-Tetrahydroxystibene

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Bcl-2 Family; MDM-2/p53

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

OC1=CC(/C=C/C2=CC=C(O)C=C2)=CC(O)=C1O

Molecular Formula

C14H12O4

Molecular Weight

244.24

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]J Lu, et al. Resveratrol analog, 3,4,5,4'-tetrahydroxystilbene, differentially induces pro-apoptotic p53/Bax gene expression and inhibits the growth of transformed cells but not their normal counterparts. Carcinogenesis. 2001 Feb;22 (2) :321-8.