Z1609609733
Z1609609733 (Compound 18) is a non-covalent 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 1.46 μM. Z1609609733 significantly inhibits serine synthesis and cancer metabolism with complete abrogation of cell proliferation[1].
Product Specifications
CAS Number
[2375374-15-3]
UNSPSC
12352005
Target
Phosphoglycerate Dehydrogenase (PHGDH)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(OC(OC(C)=O)C)C(C1=CC=C(C2(NC(C(N3C)=CC4=C3C=CC(Cl)=C4Cl)=O)COC2)C=C1)C5=CC=CN=C5
Molecular Formula
C30H27Cl2N3O6
Molecular Weight
596.46
References & Citations
[1]Mullarky E, et al. Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. Bioorg Med Chem Lett. 2019 Sep 1;29 (17) :2503-2510.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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