Verproside
Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive and anti-asthmatic activities. Verproside has the potential for the study of chronic obstructive pulmonary disease (COPD) [1].
Product Specifications
CAS Number
[50932-20-2]
UNSPSC
12352005
Hazard Statement
H319
Target
IKK; NF-κB; TNF Receptor
Related Pathways
Apoptosis; NF-κB
Field of Research
Infection; Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
OC1=C(O)C=CC(C(O[C@@H]2[C@H]3[C@@](O3)(CO)[C@@]([C@@]2([H])C=CO4)([H])[C@@H]4O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)=O)=C1
Molecular Formula
C22H26O13
Molecular Weight
498.43
Precautions
P264-P280-P305+P351+P338
References & Citations
Pseudolysimachion
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
IKK; NF-κB; TNFRSF5/CD40
Available Sizes
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