VPC-80051

VPC-80051 is an inhibitor of hnRNP A1 splicing activity. VPC-80051 directly interacts with hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line. VPC-80051 can be used in prostate cancer research[1].

Product Specifications

CAS Number

[2410979-04-1]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@H](C1=CC(F)=C(C=C1)F)NC(C2=C3C(C=CC=C3)=NN2)=O

Molecular Formula

C16H13F2N3O

Molecular Weight

301.29

References & Citations

[1]Carabet LA, et al. Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer. Molecules. 2019 Feb 20;24 (4) :763.