VPC-80051
VPC-80051 is an inhibitor of hnRNP A1 splicing activity. VPC-80051 directly interacts with hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line. VPC-80051 can be used in prostate cancer research[1].
Product Specifications
CAS Number
[2410979-04-1]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H](C1=CC(F)=C(C=C1)F)NC(C2=C3C(C=CC=C3)=NN2)=O
Molecular Formula
C16H13F2N3O
Molecular Weight
301.29
References & Citations
[1]Carabet LA, et al. Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer. Molecules. 2019 Feb 20;24 (4) :763.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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