DHPG (Standard)
DHPG (Standard) is the analytical standard of DHPG. This product is intended for research and analytical applications. DHPG is the agonist for mGluR 1/5 (EC50 for mGluR 1 is 60 nM) that activates the phospholipase C (PLC) pathway, and leads ultimately to the activation of protein kinase C (PKC) [1].
Product Specifications
CAS Number
[146255-66-5]
UNSPSC
12352100
Target
MGluR; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C(O)C(N)C1=CC(O)=CC(O)=C1
Molecular Formula
C8H9NO4
Molecular Weight
183.16
References & Citations
[1]Winder DG, et al. Metabotropic glutamate receptor (mGluR) -mediated potentiation of cyclic AMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGluR. J Neurochem. 1995 Feb;64 (2) :592-9.|[2]Pellegrini-Giampietro DE, et al. Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus. Br J Pharmacol. 1996 Jun;118 (4) :1035-43.|[3]Scotland PE, et al., Enhanced 3,5-dihydroxyphenylglycine-induced sustained nociceptive behaviors in rats with neuropathy or chronic inflammation. Behav Brain Res. 2007 Dec 3;184 (2) :150-6.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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