Syn-516
Syn-516 is an inhibitor of α-synuclein (α-Syn) . Syn-516 targets the 5' untranslated region (5'UTR) of α-Syn mRNA, with an IC50 value of 1.8 μM, thereby inhibiting the translation process of α-Syn. Syn-516 improves motor dysfunction and colonic motility abnormalities associated with α-Syn overexpression in mouse models. α-Syn can be used to study diseases such as Parkinson's disease and Lewy body dementia[1][2].
Product Specifications
CAS Number
[695209-67-7]
UNSPSC
12352005
Target
α-synuclein
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
NC1=NC(CSC2=NN=NN2C3=C4C=CC=CC4=CC=C3)=NC(N(C)C)=N1
Molecular Formula
C17H17N9S
Molecular Weight
379.44
References & Citations
[1]Cahill CM, et al. Alpha-synuclein in alcohol use disorder, connections with Parkinson’s disease and potential therapeutic role of 5’untranslated region-directed small molecules. Biomolecules. 2020 Oct 21;10 (10) :1465.|[2]Rogers JT, Cahill CM. Iron-responsive-like elements and neurodegenerative ferroptosis. Learning & Memory. 2020 Sep 1;27 (9) :395-413.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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