(22R) -Budesonide-d6

(22R) -Budesonide-d6 (Dexbudesonide-d6) is deuterium labeled (22R) -Budesonide. (22R) -Budesonide ((22R) -BUD) is the (22R) -enantiomer of Budesonide (HY-13580) . (22R) -Budesonide is a non-halogenated glucocorticoid with high local anti-inflammatory activity[1].

Product Specifications

Product Name Alternative

Dexbudesonide-d6; (22R) -BUD-d6

UNSPSC

12352005

Target

Drug Isomer; Glucocorticoid Receptor; Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Others; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

C[C@@]12[C@@]3(C(C([2H])([2H])O)=O)[C@@](O[C@H](O3)CCC)([H])C[C@@]1([H])[C@]4([H])CC([2H])([2H])C5=C([2H])C(C([2H])=C[C@]5(C)[C@@]4([H])[C@@H](O)C2)=O

Molecular Formula

C25H28D6O6

Molecular Weight

436.57

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Youming Lu, et al. Simultaneous quantification of 22R and 22S epimers of budesonide in human plasma by ultra-high-performance liquid chromatography-tandem mass spectrometry: application in a stereoselective pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Mar 15:921-922:27-34.