Alpha-Naphthoflavone (Standard)
Alpha-Naphthoflavone (Standard) is the analytical standard of Alpha-Naphthoflavone. This product is intended for research and analytical applications. Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatasearomatase. IC 50 and K I value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis[1][2][3][4].
Product Specifications
CAS Number
604-59-1
UNSPSC
12352100
Target
Apoptosis; Aryl Hydrocarbon Receptor; Cytochrome P450; Reference Standards
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C1C=C(C2=CC=CC=C2)OC3=C1C=CC4=CC=CC=C43
Molecular Formula
C19H12O2
Molecular Weight
272.30
References & Citations
[1]Campbell DR, et al. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J Steroid Biochem Mol Biol. 1993 Sep;46 (3) :381-8.|[2]Cheng YW, et al. Alpha-naphthoflavone induces vasorelaxation through the induction of extracellular calcium influx and NO formation in endothelium. Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368 (5) :377-85.|[3]Flores-Pérez A, et al. Apoptosis induction and inhibition of HeLa cell proliferation by alpha-naphthoflavone and resveratrol are aryl hydrocarbon receptor-independent. Chem Biol Interact. 2018 Feb 1;281:98-105.|[4]Xia H, et al. Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice. Biomed Pharmacother. 2019 Oct;118:109287.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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