3-Oxo-5β-cholanoic acid-d4
3-Oxo-5β-cholanoic acid-d4 (Dehydrolithocholic acid-d4) is the deuterium labeled 3-Oxo-5β-cholanoic acid (HY-125801) . 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM) [1].
Product Specifications
Product Name Alternative
Dehydrolithocholic acid-d4; 3-oxoLCA-d4
UNSPSC
12352211
Target
Isotope-Labeled Compounds; ROR
Related Pathways
Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology
Smiles
C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C([2H])([2H])C(C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@]12C)=O
Molecular Formula
C24H34D4O3
Molecular Weight
378.58
References & Citations
[1]Hang S, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec;576 (7785) :143-148.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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