3-Oxo-5β-cholanoic acid (Standard)
3-Oxo-5β-cholanoic acid (Standard) is the analytical standard of 3-Oxo-5β-cholanoic acid. This product is intended for research and analytical applications. 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM) [1].
Product Specifications
CAS Number
[1553-56-6]
Product Name Alternative
Dehydrolithocholic acid (Standard) ; 3-oxoLCA (Standard)
UNSPSC
12352211
Target
Reference Standards; ROR
Related Pathways
Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology
Smiles
C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@]4([H])CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
Molecular Formula
C24H38O3
Molecular Weight
374.56
References & Citations
[1]Hang S, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec;576 (7785) :143-148.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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