MLS000389544
MLS000389544 is a selective and potent methylsulfonylnitrobenzoate thyroid hormone receptor β (TRβ) antagonist that blocks the association of TRβ with steroid receptor coactivator 2 (SRC2) [1][2].
Product Specifications
CAS Number
573965-48-7
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Thyroid Hormone Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Smiles
O=C(OCC(NC1(C2)CC3CC2CC(C3)C1)=O)C4=CC=C(S(=O)(C)=O)C([N+]([O-])=O)=C4
Molecular Formula
C20H24N2O7S
Molecular Weight
436.48
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501
References & Citations
[1]Mire Zloh, et al. Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists. Life Sci. 2016 Feb 1:146:66-72. |[2]"Ronald L Johnson, et al. A Quantitative High-hroughput Screen Identifies ovel Inhibitors of the Interaction of hyroid eceptor β with a Peptide of Steroid eceptor oactivator 2. J Biomol Screen . 2011 Jul;16 (6) :618-27."
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
301325-ML490 100 µL
CD100 (Semaphorin 4D, Leukocyte Semaphorin, CD 100, CD-100) (MaxLight 490) discontinued
Sign In for Pricing
View Details ![Rat Monoclonal CX3CL1/Fractalkine Antibody (126315) [Janelia Fluor 646]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
FAB571J 0.1 mL
Rat Monoclonal CX3CL1/Fractalkine Antibody (126315) [Janelia Fluor 646]
Sign In for Pricing
View Details 
251456-APC 100 µL
SCN11A (Sodium Channel, Voltage-gated, Type XI, alpha Subunit, NAV1.9, NaN, SCN12A, SNS-2) (APC)
Sign In for Pricing
View Details