MLS000389544

MLS000389544 is a selective and potent methylsulfonylnitrobenzoate thyroid hormone receptor β (TRβ) antagonist that blocks the association of TRβ with steroid receptor coactivator 2 (SRC2) [1][2].

Product Specifications

CAS Number

[573965-48-7]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Thyroid Hormone Receptor

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease

Smiles

O=C(OCC(NC1(C2)CC3CC2CC(C3)C1)=O)C4=CC=C(S(=O)(C)=O)C([N+]([O-])=O)=C4

Molecular Formula

C20H24N2O7S

Molecular Weight

436.48

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Mire Zloh, et al. Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists. Life Sci. 2016 Feb 1:146:66-72. |[2]"Ronald L Johnson, et al. A Quantitative High-hroughput Screen Identifies ovel Inhibitors of the Interaction of hyroid eceptor β with a Peptide of Steroid eceptor oactivator 2. J Biomol Screen . 2011 Jul;16 (6) :618-27."