5-Phenylhydantoin (Standard)
Dasatinib (monohydrate) (Standard) is the analytical standard of Dasatinib (monohydrate) . This product is intended for research and analytical applications. Dasatinib (BMS-354825) monohydrate is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib monohydrate inhibits Bcr-Abl and Src with IC50s of [1]. Dasatinib monohydrate also induces apoptosis and autophagy.
Product Specifications
CAS Number
[89-24-7]
UNSPSC
12352005
Target
Drug Metabolite; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Neurological Disease; Cardiovascular Disease
Smiles
O=C1NC(C(C2=CC=CC=C2)N1)=O
Molecular Formula
C9H8N2O2
Molecular Weight
176.18
References & Citations
[1]Maguire JH, et al. Hypolipidemic activity of antiepileptic 5-phenylhydantoins in mice. Eur J Pharmacol. 1985 Oct 29;117 (1) :135-8.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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