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Disopyramide (phosphate) (Standard)

Disopyramide (phosphate) (Standard) is the analytical standard of Disopyramide (phosphate) . This product is intended for research and analytical applications. Disopyramide phosphate is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide phosphate blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide phosphate inhibits HERG encoded potassium channels. Disopyramide phosphate also exhibits complex protein binding, and has a potent negative inotropic action[1][2][3].

Product Specifications

CAS Number

22059-60-5

UNSPSC

12352100

Target

Potassium Channel; Reference Standards; Sodium Channel

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Cardiovascular Disease

Smiles

O=P(O)(O)O.NC(C(C1=CC=CC=C1)(C2=CC=CC=N2)CCN(C(C)C)C(C)C)=O

Molecular Formula

C21H32N3O5P

Molecular Weight

437.47

References & Citations

[1]S V Jones, et al. Non-competitive Effects of Disopyramide at the Neuromuscular Junction: Evidence for Endplate Ion Channel Block. Br J Anaesth. 1987 Jun;59 (6) :776-83.|[2]L A Siddoway, et al. Clinical Pharmacokinetics of Disopyramide. Clin Pharmacokinet. May-Jun 1986;11 (3) :214-22.|[3]A A Paul, et al. Inhibition of HERG Potassium Channel Current by the Class 1a Antiarrhythmic Agent Disopyramide. Biochem Biophys Res Commun. 2001 Feb 9;280 (5) :1243-50.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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