PSB-1737
PSB-1737 is a human-selective GPR17 agonist with an EC50 for human GPR17 of 270 nM, and its activity on murine GPR17 is relatively weak (EC50 > 10 μM) . PSB-1737 shows no significant inhibition at the glycine binding site of NMDA receptors, and has no significant agonistic or antagonistic activity on P2Y receptor subtypes. PSB-1737 can be used in demyelinating diseases (such as multiple sclerosis) or inflammatory-related anemia[1].
Product Specifications
CAS Number
139896-80-3
UNSPSC
12352005
Target
Orphan GPCR
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Smiles
O=C(C1=C(CCC(O)=O)C2=C(C=C(C=C2)OC3=CC=CC=C3)N1)O
Molecular Formula
C18H15NO5
Molecular Weight
325.32
References & Citations
[1]Baqi Y, et al. 3- (2-Carboxyethyl) indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17. J Med Chem. 2018 Sep 27;61 (18) :8136-8154.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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