SKF 38393 (hydrochloride) (Standard)

SKF 38393 (hydrochloride) (Standard) is the analytical standard of SKF 38393 (hydrochloride) . This product is intended for research and analytical applications. SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM[1].

Product Specifications

CAS Number

[62717-42-4]

UNSPSC

12352100

Target

Dopamine Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1.[H]Cl

Molecular Formula

C16H18ClNO2

Molecular Weight

291.77

References & Citations

[1]Altar CA, et al. Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction auto radiography. J Neurosci. 1987 Jan;7 (1) :213-222.|[2]Mayerhofer A, et al. Functional Dopamine-1 Receptors and DARPP-32 Are Expressed in Human Ovary and Granulosa Luteal Cells in Vitro. J Clin Endocrinol Metab. 1999 Jan;84 (1) :257-64.|[3]Muralikrishnan D, et al. SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Brain Res. 2001 Feb 23;892 (2) :241-7.|[4]Bouron A, et al. The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus. Neuroscience. 1999;94 (4) :1063-70.