Indazole 1
Indazole 1 is a potent CDC2-like kinase 2 (CLK2) inhibitor (IC50=12.3 nM) . Indazole 1 inhibits the phosphorylation of SR proteins (e.g., SRSF1, SRSF3) and modulates alternative splicing of Wnt signaling-related genes. Indazole 1 is promising for research of osteoarthritis[1].
Product Specifications
CAS Number
2252153-37-8
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Inflammation/Immunology
Smiles
CC(C)C[C@H](N)COC1=CC(C2=CC3=C(NN=C3C)C=C2)=CN=C1
Molecular Formula
C19H24N4O
Molecular Weight
324.42
References & Citations
[1]Sun Y, et al. Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis. J Med Chem. 2024 Mar 28;67 (6) :4603-4623.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CLK
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