SKF 38393

SKF 38393 is a selective dopamine D1 receptor agonist. SKF 38393 activates the cAMP signaling pathway and promotes dopamine release in the developing rat striatum. SKF 38393 inhibits MCF-7 breast cancer cell proliferation (IC50=0.1 μM) . SKF 38393 is promising for research of neurodevelopmental disorders, dopamine-related diseases (e.g., Parkinson’s, dopamine deficiency), and cancers[1][2].

Product Specifications

CAS Number

[67287-49-4]

UNSPSC

12352005

Target

Dopamine Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cancer; Neurological Disease

Solubility

10 mM in DMSO

Smiles

OC1=C(O)C=C(C(CNCC2)C3=CC=CC=C3)C2=C1

Molecular Formula

C16H17NO2

Molecular Weight

255.31

References & Citations

[1]Walters DE, et al. The D1 agonist SKF 38393 increases dopamine release in the developing rat striatum. Eur J Pharmacol. 1990 Aug 10;184 (2-3) :257-64.|[2]Johnson DE, et al. The growth inhibitory properties of a dopamine agonist (SKF 38393) on MCF-7 cells. Anticancer Drugs. 1995 Jun;6 (3) :471-4.