SKF 38393
SKF 38393 is a selective dopamine D1 receptor agonist. SKF 38393 activates the cAMP signaling pathway and promotes dopamine release in the developing rat striatum. SKF 38393 inhibits MCF-7 breast cancer cell proliferation (IC50=0.1 μM) . SKF 38393 is promising for research of neurodevelopmental disorders, dopamine-related diseases (e.g., Parkinson’s, dopamine deficiency), and cancers[1][2].
Product Specifications
CAS Number
67287-49-4
UNSPSC
12352005
Target
Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cancer; Neurological Disease
Solubility
10 mM in DMSO
Smiles
OC1=C(O)C=C(C(CNCC2)C3=CC=CC=C3)C2=C1
Molecular Formula
C16H17NO2
Molecular Weight
255.31
References & Citations
[1]Walters DE, et al. The D1 agonist SKF 38393 increases dopamine release in the developing rat striatum. Eur J Pharmacol. 1990 Aug 10;184 (2-3) :257-64.|[2]Johnson DE, et al. The growth inhibitory properties of a dopamine agonist (SKF 38393) on MCF-7 cells. Anticancer Drugs. 1995 Jun;6 (3) :471-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D1 Receptor
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