ULK-100

ULK-100 is a highly selective and potent ULK1 kinase inhibitor with an IC50 value of 1.6 nM. ULK-100 is promising for research of autophagy-related diseases (e.g., KRAS-mutant lung cancer, glioblastoma) [1].

Product Specifications

CAS Number

[945377-65-1]

UNSPSC

12352005

Target

ULK

Related Pathways

Autophagy

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(C1=CC(C2=C3N=CC(C4=CC=C(OCCN5CCCCC5)C=C4)=CN3N=C2)=CS1)N[C@@H](C(C)C)C(F)(F)F

Molecular Formula

C29H32F3N5O2S

Molecular Weight

571.66

References & Citations

[1]Martin KR, et al. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct 26;8:74-84.