ULK-100
ULK-100 is a highly selective and potent ULK1 kinase inhibitor with an IC50 value of 1.6 nM. ULK-100 is promising for research of autophagy-related diseases (e.g., KRAS-mutant lung cancer, glioblastoma) [1].
Product Specifications
CAS Number
[945377-65-1]
UNSPSC
12352005
Target
ULK
Related Pathways
Autophagy
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C1=CC(C2=C3N=CC(C4=CC=C(OCCN5CCCCC5)C=C4)=CN3N=C2)=CS1)N[C@@H](C(C)C)C(F)(F)F
Molecular Formula
C29H32F3N5O2S
Molecular Weight
571.66
References & Citations
[1]Martin KR, et al. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct 26;8:74-84.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ULK1
Curated Selection
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