NWL-117

NWL-117 is a brain-penetrant and highly selective Caspase-6 (Casp6) inhibitor with an IC50 value of 192 nM. NWL-117 is promising for research of neurodegenerative diseases, particularly Alzheimer's disease and Huntington's disease [1].

Product Specifications

CAS Number

2267318-43-2

UNSPSC

12352005

Target

Caspase

Related Pathways

Apoptosis

Field of Research

Neurological Disease

Smiles

O=C(O)[C@@H](/C=C/S(=O)(C)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)=O

Molecular Formula

C29H42N4O11S

Molecular Weight

654.73

References & Citations

[1]Pakavathkumar P, et al. Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice. Mol Neurodegener. 2017 Feb 28;12 (1) :22.