BMS-818251

BMS-818251 is a potent, small-molecule inhibitor of HIV-1 entry with an EC50 value of 0.019 nM. BMS-818251 shows >10-fold higher potency than BMS-626529 (HY-15440) on a cross-clade panel of 208-HIV-1 strains. BMS-818251 interacts with gp120 residues from the conserved β20-β21 hairpin to improve potency[1].

Product Specifications

CAS Number

[2974489-09-1]

UNSPSC

12352005

Target

HIV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

N#C/C(C1=CC=CC=C1)=C2CCN(CC/2)C(C(C3=CNC4=C(C5=CSC(C(NCCO)=O)=N5)N=CC(OC)=C34)=O)=O

Molecular Formula

C29H26N6O5S

Molecular Weight

570.62

References & Citations

[1]Lai YT, et al. Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry. Nat Commun. 2019 Jan 3;10 (1) :47.