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Desogestrel-13C2, d2-1

Desogestrel-13C2, d2-1 (Org-2969-13C2, d2-1) is the deuterium labeled and 13C-labeled Desogestrel. Desogestrel (Org-2969) is a third-generation progesterone analogue contained in many oral contraceptive preparations. Desogestrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1][2][3][4].

Product Specifications

Product Name Alternative

Org-2969-13C2, d2-1

UNSPSC

12352211

Target

Isotope-Labeled Compounds; Progesterone Receptor

Related Pathways

Others; Vitamin D Related/Nuclear Receptor

Field of Research

Others

Smiles

[H][C@@]12C(CC[C@]([H])([C@@]23[H])[C@@]([H])([C@@]4(CC3=C)CC)CC([2H])([C@@]4(O)[13C]#[13CH])[2H])=CCCC1

Molecular Formula

C20 13C2H28D2O

Molecular Weight

314.47

References & Citations

[1]Rosenberg MJ, et al. The effect of desogestrel, gestodene, and other factors on spotting and bleeding. Contraception. 1996 Feb;53 (2) :85-90.|[2]Barkfeldt J, et al. The effects of two progestogen-only pills containing either desogestrel (75 microg/day) or levonorgestrel (30 microg/day) on lipid metabolism. Contraception. 2001 Nov;64 (5) :295-9.|[3]Grandi G, et al. Pharmacokinetic evaluation of desogestrel as a female contraceptive. Expert Opin Drug Metab Toxicol. 2014 Jan;10 (1) :1-10.|[4]Cardani S, et al., Desogestrel down-regulates PHOX2B and its target genes in progesterone responsive neuroblastoma cells. Exp Cell Res. 2018 Sep 15;370 (2) :671-679.|[5]Xie H, et al., Effect of progestin on thyroid function in female Wistar rats. Front Endocrinol (Lausanne) . 2024 Jun 5;15:1362774.|[6]Gassen DT, et al. Evaluation of hormonal suppression with two contraceptive regimens using ethinyl estradiol and desogestrel. Arch Gynecol Obstet. 2013 Feb;287 (2) :289-94.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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