HOI-07

HOI-07 is a selective Aurora B kinase inhibitor. HOI-07 blocks phosphorylation of histone H3 on Ser10 in lung cancer cells. HOI-07 induces cell-cycle arrest, and apoptosis. HOI-07 has antitumor activity, and suppresses the tumor growth of A549, 143B and KHOS xenografts[1][2].

Product Specifications

CAS Number

[1451013-67-4]

UNSPSC

12352005

Target

Apoptosis; Aurora Kinase

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C1NC2=C(/C1=C\C(/C=C/C3=CC=C4OCOC4=C3)=O)C=CC=C2

Molecular Formula

C19H13NO4

Molecular Weight

319.31

References & Citations

[1]Xie H, et al. Identification of an Aurora kinase inhibitor specific for the Aurora B isoform. Cancer Res. 2013 Jan 15;73 (2) :716-24.|[2]Zhao Z, et al. Aurora B kinase as a novel molecular target for inhibition the growth of osteosarcoma. Mol Carcinog. 2019 Jun;58 (6) :1056-1067.