Diptoindonesin G
Diptoindonesin G is a 2-arylbenzofuran derivative and a modulator of estrogen receptor and HSP90 middle domain. Diptoindonesin G exhibits strong cytotoxicity against mouse leukemia P-388 cells with an IC50 of 13.2 μM. Diptoindonesin G has antitumor activity and can be used in the research of tumors such as breast cancer[1][2][3].
Product Specifications
CAS Number
1190948-58-3
UNSPSC
12352005
Target
Estrogen Receptor/ERR; HSP
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1C2=C3C(OC(C4=CC=C(O)C=C4)=C3C5=C1C(O)=CC(O)=C5)=CC(O)=C2
Molecular Formula
C21H12O6
Molecular Weight
360.32
References & Citations
[1]Juliawaty LD, et al. A 2-arylbenzofuran derivative from Hopea mengarawan. Nat Prod Commun. 2009 Jul;4 (7) :947-50.|[2]Liu JT, et al. Total synthesis of diptoindonesin G and its analogues as selective modulators of estrogen receptors. Org Biomol Chem. 2016 Sep 26;14 (38) :8927-8930.|[3]Donahue K, et al. Diptoindonesin G is a middle domain HSP90 modulator for cancer treatment. J Biol Chem. 2022 Dec;298 (12) :102700.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TP320460 20 µg
Integrin Linked Kinase (ILK) (NM_001014794) Human Recombinant Protein
Sign In for Pricing
View Details 
