JH-IX-179
JH-IX-179 is an FLT3 inhibitor (IC50 = 4 nM (FLT3-ITD), 10 nM (FLT3-D835Y) ) . JH-IX-179 inhibits G1 phase arrest and induces apoptosis in FLT3-ITD-expressing cells. JH-IX-179 can be used in acute myeloid leukemia (AML) research[1].
Product Specifications
CAS Number
1939104-08-1
UNSPSC
12352005
Target
Apoptosis; FLT3
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1C2=C(C(N3)=C1C4=C3C=C(C5=CNN=C5)C=C4)C=C(C6=CN(CCCN(C)C)N=C6)C=C2
Molecular Formula
C26H24N6O
Molecular Weight
436.51
References & Citations
[1]Hatcher JM, et al. Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor. ACS Med Chem Lett. 2016 Mar 8;7 (5) :476-81.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC700391-100 1x 100 µL
CD81 / TAPA-1 (1.3.3.22), CF770 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400270-100 1x 100 µL
Fibronectin (HFN7.1), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940806-500 1x 500 µL
TYRP1 (Tyrosinase Related Protein 1) (TA99), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC881712-100 1x 100 µL
GP2 (Glycoprotein 2) / ZAP75 (GP2/1712), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC042561-100 1x 100 µL
NKX6.1 (Marker for Pancreatic and Duodenal Neuroendocrine Tumors) (NKX61/2561), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details