BMS-986126
BMS-986126 is a potent, selective, and orally active IRAK4 inhibitor (IC50 = 5.3 nM) . BMS-986126 broadly inhibits MyD88-dependent signaling pathways. BMS-986126 demonstrates robust activity in the MRL/lpr and NZB/NZW murine models of lupus, inhibiting multiple pathogenic responses. BMS-986126 can be used for autoimmune diseases research, such as lupus erythematosus (SLE) [1].
Product Specifications
CAS Number
1610017-20-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
ERK; Interleukin Related; IRAK; NF-κB; Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
CC(C)(O)[C@H](F)CNC(C(C(NC1CC1)=C2)=CN=C2NC3=NC4=C(C=NC=C4)C=C3)=O
Molecular Formula
C22H25FN6O2
Molecular Weight
424.47
Precautions
P261-P280-P302+P352
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4
Frequently Asked Questions
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