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VU6010608

VU6010608 is a blood-brain barrier-crossing mGlu7 negative allosteric modulator (IC50 = 0.76 μM) . VU6010608 can block long-term enhancement (LTP) of SC-CA1 synapses in mouse brain slices induced by high-frequency stimulation. VU6010608 can be used for research on neurological diseases[1].

Product Specifications

CAS Number

2165325-42-6

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

MGluR

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(NC1=CC(OC(F)(F)F)=CC=C1N2N=CN=C2)C3=CC=C(OC)C(OC)=C3

Molecular Formula

C18H15F3N4O4

Molecular Weight

408.33

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Reed CW, et al.VU6010608, a Novel mGlu7 NAM from a Series of N- (2- (1H-1,2,4-Triazol-1-yl) -5- (trifluoromethoxy) phenyl) benzamides. ACS Med Chem Lett. 2017 Nov 8;8 (12) :1326-1330.

Shipping Conditions

Room temperature

Scientific Category

Reference compound2

Clinical Information

No Development Reported

Frequently Asked Questions

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