MK-8282
MK-8282 is a potent, orally active GPR-119 agonist. MK-8282 shows improved glucose tolerance. MK-8282 can be used in the research of type 2 diabetes[1].
Product Specifications
CAS Number
1147556-27-1
UNSPSC
12352005
Target
GPR119
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Metabolic Disease
Smiles
N#CC1=CC(Cl)=C(NC2=C(F)C(O[C@@]3([H])[C@@H]4CN(C(OC5(CC5)C)=O)C[C@H]3COC4)=NC=N2)C=C1
Molecular Formula
C23H23ClFN5O4
Molecular Weight
487.91
References & Citations
[1]Neelamkavil SF, et al. Discovery of MK-8282 as a Potent G-Protein-Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2018 Apr 10;9 (5) :457-461.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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