7,3',4'-Trihydroxyisoflavone (Standard)

7,3',4'-Trihydroxyisoflavone (Standard) is the analytical standard of 7,3',4'-Trihydroxyisoflavone. This product is intended for research and analytical applications. 7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities[1][2].

Product Specifications

CAS Number

[485-63-2]

UNSPSC

12352100

Target

Apoptosis; MAP3K; Reference Standards

Related Pathways

Apoptosis; MAPK/ERK Pathway; Others

Field of Research

Cancer

Smiles

OC1=CC=C2C(C(C3=CC(O)=C(C=C3)O)=COC2=C1)=O

Molecular Formula

C15H10O5

Molecular Weight

270.24

References & Citations

[1]Yu-Li Lo, et al. 7,3',4'-Trihydroxyisoflavone modulates multidrug resistance transporters and induces apoptosis via production of reactive oxygen species. Toxicology. 2012 Dec 16;302 (2-3) :221-32. |[2]Dong Eun Lee, et al. 7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4. J Biol Chem. 2011 Apr 22;286 (16) :14246-56.