Tylophorinicine

Tylophorinicine is an anti-leukemic and anti-fungal agent. Tylophorinicine exhibits minimum inhibitory concentrations (MIC) in the range of 2-4 mg/mL for TdnH and 0.6-2.5 mg/mL for TnnH against Candida species. Tylophorinicine is a phenanthroindolizidine alkaloid from tylophora asthamatica and pergulatia pallid. Tylophorinicine inhibits thymidylate synthase by pergularinine[1][2][3].

Product Specifications

CAS Number

[87302-57-6]

UNSPSC

12352005

Target

Fungal

Related Pathways

Anti-infection

Field of Research

Cancer; Infection

Smiles

O[C@@H]1C2=C(C=C(C(OC)=C3)OC)C3=C(C=C(C(OC)=C4)OC)C4=C2CN5[C@@]1([H])CCC5

Molecular Formula

C24H27NO5

Molecular Weight

409.47

References & Citations

[1]Mostafa EM, et al., In Vitro Anti-Proliferative, and Kinase Inhibitory Activity of Phenanthroindolizidine Alkaloids Isolated from Tylophora indica. Plants (Basel) . 2022 May 12;11 (10) :1295. |[2]N.B. Mulchandani and S.R. Venkatachalam. Tylophorinicine, a phenanthroindolizidine alkaloid from tylophora asthmatica and pergularia pallida. (1984) 23 (5) 1206.|[3]Dhiman M, et al., Antifungal activity of hydrochloride salts of tylophorinidine and tylophorinine. Nat Prod Commun. 2012 Sep;7 (9) :1171-2.