MI-223
MI-223 is a Mcl-1 regulator (Kd = 160 nM) . MI-223 binds to the BH1 domain, blocking Mcl-1-stimulated homologous recombination DNA repair, thus sensitizing cancer cells to DNA replication agents. MI-223 can be used in research on cancers such as lung cancer[1].
Product Specifications
CAS Number
[907166-59-0]
UNSPSC
12352005
Target
Bcl-2 Family
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1N(/N=C/C2=CC=CC(OCC)=C2O)C(C3=CC=CC=C3Cl)=NC4=C1C=CC=C4
Molecular Formula
C23H18ClN3O3
Molecular Weight
419.86
References & Citations
[1]Chen G, et al. Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy. J Clin Invest. 2018 Jan 2;128 (1) :500-516.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
More Discoveries
Explore Other Products
Browse additional items from our catalog
FAB4405I 0.1 mL
Mouse Monoclonal mGluR7 Antibody (437310) [Janelia Fluor 549]
Sign In for Pricing
View Details