MI-223
MI-223 is a Mcl-1 regulator (Kd = 160 nM) . MI-223 binds to the BH1 domain, blocking Mcl-1-stimulated homologous recombination DNA repair, thus sensitizing cancer cells to DNA replication agents. MI-223 can be used in research on cancers such as lung cancer[1].
Product Specifications
CAS Number
[907166-59-0]
UNSPSC
12352005
Target
Bcl-2 Family
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1N(/N=C/C2=CC=CC(OCC)=C2O)C(C3=CC=CC=C3Cl)=NC4=C1C=CC=C4
Molecular Formula
C23H18ClN3O3
Molecular Weight
419.86
References & Citations
[1]Chen G, et al. Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy. J Clin Invest. 2018 Jan 2;128 (1) :500-516.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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