X-370
X-370 is a PI3Kδ inhibitor (IC50 = 7 nM) . X-370 inhibits the survival of leukemia cells, inducing G1 arrest and apoptosis. X-370 blocks PDK1 binding and phosphorylation of MEK1/2, eliminating Akt and Erk1/2 signaling. X-370 can be used in research on B-cell acute lymphoblastic leukemia (B-ALL) [1].
Product Specifications
CAS Number
1280725-80-5
UNSPSC
12352005
Target
Akt; Apoptosis; ERK; MEK; PDK-1; PI3K
Related Pathways
Apoptosis; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Cancer
Smiles
FC(F)C1=NC2=C(N1C3=NC(N4CCOCC4)=NC5=C3N=CN5C6CCN(C(N7CCCC7)=O)CC6)C=CC=C2
Molecular Formula
C27H31F2N9O2
Molecular Weight
551.59
References & Citations
[1]Wang X, et al. Simultaneous targeting of PI3Kδ and a PI3Kδ-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia. Oncotarget. 2014 Nov 15;5 (21) :10732-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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