ASP 8477
ASP 8477 is an orally active and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 values of 3.99, 1.65, and 57.3 nM for human FAAH-1, FAAH-1 (P129T), and FAAH-2, respectively. ASP 8477 has central nervous system activity and can be used in analgesia research[1].
Product Specifications
CAS Number
[906737-25-5]
UNSPSC
12352005
Target
FAAH
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(N1CCC(C(NC2=CC=CC=C2)=O)CC1)OC3=CC=CN=C3
Molecular Formula
C18H19N3O3
Molecular Weight
325.36
References & Citations
[1]Watabiki T, et al. In vitro and in vivo pharmacological characterization of ASP8477: A novel highly selective fatty acid amide hydrolase inhibitor[J]. European Journal of Pharmacology, 2017, 815: 42-48.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
FAAH-1; FAAH-2
Available Sizes
Curated Selection
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