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ASP 8477

ASP 8477 is an orally active and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 values ​​of 3.99, 1.65, and 57.3 nM for human FAAH-1, FAAH-1 (P129T), and FAAH-2, respectively. ASP 8477 has central nervous system activity and can be used in analgesia research[1].

Product Specifications

CAS Number

906737-25-5

UNSPSC

12352005

Target

FAAH

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(N1CCC(C(NC2=CC=CC=C2)=O)CC1)OC3=CC=CN=C3

Molecular Formula

C18H19N3O3

Molecular Weight

325.36

References & Citations

[1]Watabiki T, et al. In vitro and in vivo pharmacological characterization of ASP8477: A novel highly selective fatty acid amide hydrolase inhibitor[J]. European Journal of Pharmacology, 2017, 815: 42-48.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

FAAH-1; FAAH-2

Available Sizes

Frequently Asked Questions

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