Pyrimidinone 8
Pyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 (DMT1), with a Ki of 20 μM (hDMT1) . Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence with the extracellular pH. Pyrimidinone 8 can inhibit hDMT1-mediated iron uptake, with an IC50 of 13.8 μM[1].
Product Specifications
CAS Number
[65004-42-4]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Ferroportin
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Smiles
O=C1N=C(N2N=C(C)C=C2C)NC(C)=C1
Molecular Formula
C10H12N4O
Molecular Weight
204.23
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-124703/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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