AMXT-1501 tetrahydrochloride

AMXT-1501 tetrahydrochloride is an orally active polyamine transport inhibitor. AMXT1501 blocks tumor growth in immunocompetent mice but not in athymic nude mice lacking T cells[1]. Combination of DFMO and AMXT-1501 induces caspase-3 mediated apoptosis in NB cell lines[2].

Product Specifications

CAS Number

[2444815-84-1]

UNSPSC

12352211

Target

Apoptosis

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Purity

98.0

Solubility

H2O : 83.33 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCCCCC(NCCCC[C@@H](N)C(NCCCNCCCCNCCCN)=O)=O.Cl.Cl.Cl.Cl

Molecular Formula

C32H72Cl4N6O2

Molecular Weight

714.77

References & Citations

[1]Candace S Hayes, et al. Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment. Cancer Immunol Res. 2014 Mar;2 (3) :274-85.|[2]Ruohan Wu, et al. De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function. Sci Adv. 2020 Dec 16;6 (51) :eabc4275.|[3]Katherine Samal, et al. AMXT‐1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport. Int J Cancer. 2013 Sep 15;133 (6) :1323-33.