AMXT-1501 tetrahydrochloride
AMXT-1501 tetrahydrochloride is an orally active polyamine transport inhibitor. AMXT1501 blocks tumor growth in immunocompetent mice but not in athymic nude mice lacking T cells[1]. Combination of DFMO and AMXT-1501 induces caspase-3 mediated apoptosis in NB cell lines[2].
Product Specifications
CAS Number
[2444815-84-1]
UNSPSC
12352211
Target
Apoptosis
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Purity
98.0
Solubility
H2O : 83.33 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCCCCCC(NCCCC[C@@H](N)C(NCCCNCCCCNCCCN)=O)=O.Cl.Cl.Cl.Cl
Molecular Formula
C32H72Cl4N6O2
Molecular Weight
714.77
References & Citations
[1]Candace S Hayes, et al. Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment. Cancer Immunol Res. 2014 Mar;2 (3) :274-85.|[2]Ruohan Wu, et al. De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function. Sci Adv. 2020 Dec 16;6 (51) :eabc4275.|[3]Katherine Samal, et al. AMXT‐1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport. Int J Cancer. 2013 Sep 15;133 (6) :1323-33.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
Emerg Microbes Infect. 2024 Dec;13 (1) :2321981.|Immunity. 2025 Aug 12;58 (8) :2019-2034.e11.|Nat Commun. 2024 Mar 19;15 (1) :2461.|Neuro Oncol. 2025 May 27:noaf128.|Research Square Preprint. 2024 Mar 19.|The University of Texas at San Antonio. 2025.|bioRxiv. 2024 Nov 17:2024.08.24.609500.|bioRxiv. 2025 January 26.|Cell Death Differ. 2024 Jul;31 (7) :910-923.|Immunity. 2025 Aug 12;58 (8) :2019-2034.e11.
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