IQS-019

IQS-019 is a B cell receptor (BCR) kinase inhibitor. IQS-019 can inhibit the de-phosphorylation of constitutive and IgM-activated Syk, Lyn, and Btk. IQS-019 can inhibit cell proliferation, migration and induce apoptosis. IQS-019 exhibits antitumor activity and can be used for the research of cancer, such as B cell lymphoma[1].

Product Specifications

CAS Number

[1630804-24-8]

UNSPSC

12352005

Target

Apoptosis; Btk; Syk

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C1C(C2=C(Cl)C=CC=C2Cl)=CC3=C(N)N=C(NC4=CC=C(N5CCN(C)CC5)C=C4)N=C3N1C

Molecular Formula

C25H25Cl2N7O

Molecular Weight

510.42

References & Citations

[1]Balsas P, et al. Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma. J Hematol Oncol. 2017 Mar 31;10 (1) :80.