DPN (Standard)
DPN (Standard) is the analytical standard of DPN. This product is intended for research and analytical applications. DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases[1][2].
Product Specifications
CAS Number
1428-67-7
UNSPSC
12352100
Target
Apoptosis; Autophagy; Estrogen Receptor/ERR; Reference Standards
Related Pathways
Apoptosis; Autophagy; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Neurological Disease
Smiles
OC1=CC=C(CC(C#N)C2=CC=C(O)C=C2)C=C1
Molecular Formula
C15H13NO2
Molecular Weight
239.27
References & Citations
[1]Suwanna N, et al. Neuroprotective effects of diarylpropionitrile against β-amyloid peptide-induced neurotoxicity in rat cultured cortical neurons. Neurosci Lett. 2014 Aug 22;578:44-9.|[2]Meyers, M. J., et al. Estrogen Receptor-β Potency-Selective Ligands: Structure−Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues. Journal of Medicinal Chemistry, 2001. 44 (24), 4230–4251.|[3]Fuzhong Yang, et al. Physiological dosages of estradiol and diarylpropionitrile decrease depressive behavior and increase tryptophan hydroxylase expression in the dorsal raphe nucleus of rats subjected to the forced swim test. Neuroreport. 2019 Jan 16;30 (2) :66-70.|[4]Sherry A. Said, et al. Effects of long-term dietary administration of estrogen receptor-beta agonist diarylpropionitrile on ovariectomized female ICR (CD-1) mice. GeroScience. 2018 Aug; 40 (4) : 393–403.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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