DPN (Standard)

DPN (Standard) is the analytical standard of DPN. This product is intended for research and analytical applications. DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases[1][2].

Product Specifications

CAS Number

[1428-67-7]

UNSPSC

12352100

Target

Apoptosis; Autophagy; Estrogen Receptor/ERR; Reference Standards

Related Pathways

Apoptosis; Autophagy; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Neurological Disease

Smiles

OC1=CC=C(CC(C#N)C2=CC=C(O)C=C2)C=C1

Molecular Formula

C15H13NO2

Molecular Weight

239.27

References & Citations

[1]Suwanna N, et al. Neuroprotective effects of diarylpropionitrile against β-amyloid peptide-induced neurotoxicity in rat cultured cortical neurons. Neurosci Lett. 2014 Aug 22;578:44-9.|[2]Meyers, M. J., et al. Estrogen Receptor-β Potency-Selective Ligands: Structure−Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues. Journal of Medicinal Chemistry, 2001. 44 (24), 4230–4251.|[3]Fuzhong Yang, et al. Physiological dosages of estradiol and diarylpropionitrile decrease depressive behavior and increase tryptophan hydroxylase expression in the dorsal raphe nucleus of rats subjected to the forced swim test. Neuroreport. 2019 Jan 16;30 (2) :66-70.|[4]Sherry A. Said, et al. Effects of long-term dietary administration of estrogen receptor-beta agonist diarylpropionitrile on ovariectomized female ICR (CD-1) mice. GeroScience. 2018 Aug; 40 (4) : 393–403.